Build Strength. Protect Your Brain.
An evidence-based coaching program to help prevent, slow, and mitigate cognitive decline — integrating neuroscience, lifestyle medicine, and cutting-edge research into one personalized plan.
Founded by Johns Hopkins-trained neuroscientist and exercise physiologist Dr. Alfonso Alfini, PhD, MS, CSCS
Dementia Is a Global Crisis — But Its Not Inevitable.
Every 3 Seconds
Someone develops dementia — yet up to 45% of cases may be preventable.
Science shows that by addressing 14 key risk factors, we can prevent, slow, and mitigate cognitive decline.
The number of people living with dementia is expected
to triple by 2050.
The Future of Brain Health Starts with Strength.
E4 STRENGTH
E4 STRENGTH is the first muscle-driven brain health program, turning cutting edge neuroscience into a structured, personalized plan to help prevent, slow, and mitigate cognitive decline.
Your brain and body are connected — and your muscle strength is one of the most powerful predictors of long-term cognitive resilience. E4 STRENGTH integrates exercise, sleep, nutrition, and connection into a precision lifestyle framework designed to maximize both performance and protection.
E4 STRENGTH
EXERCISE ● SLEEP ● NUTRITION ● CONNECTION
The Four Pillars of Cognitive Resilience
The E4 STRENGTH framework is built on four scientifically validated pillars that support muscle-driven brain health and protect long-term cognitive performance.
Four Pillars of Muscle-Driven Brain Health
Strength-centered habits that compound: Exercise, Sleep, Nutrition, and Connection.
Exercise
Build and maintain muscle to power your brain and body.
Sleep
Optimize deep recovery, memory, and circadian alignment.
Nutrition
Fuel neuroprotection with MIND-inspired eating, hydration, and supplementation.
Connection
Stay cognitively sharp through engagement, monitoring, and meaningful relationships.